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Gabriel Roman Souza Author
Subjects of specialization
Affiliation
cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Department of Pathology, University of Texas Health Science Center San Antonio, Texas, United States of America
Biography
Dr. Gabriel Roman Souza is working as scientist and professor at Department of Pathology, University of Texas Health Science Center San Antonio, Texas, United States of America. The author has specalization in cancer, cancer oncology, chemotherapy, Carcinogenesis, Chemotherapy
Publications
Case Report Subscription
Metastatic Thymic Carcinoma with novel KIT mutations masquerading as a Carcinoma of Unknown Primary Site
Author(s): Gabriel Roman Souza, Sarah Hackman, Kayla E Chamberlin, Dmytro Kovalskyy, Amy L Mumbower and Daruka Mahadevan
A patient diagnosed with thymic carcinoma was found to have three KIT mutations (F522C, V560del, and Y823S), two of them not previously documented. In addition, this is the first reported case of thymic carcinoma with more than one pathogenic KIT mutation. He was initially treated with imatinib mesylate (IM) with a minor response. Subsequently, IM was discontinued, and he was treated with cisplatin plus gemcitabine with clinical and radiologic response. A repeat liquid biopsy showed total suppression of V560del, Y823S, F522C, and KRAS amplification.
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