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Hindi Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777
Gareth Wakefield Author
Subjects of specialization
Affiliation
Nanoscience, Nanotubes, Nanomaterials, Nanotechnology, Nanoparticles.
Xerion Healthcare Ltd, Cherwell Innovation Centre, 77 Heyford Park, Upper Heyford, Oxfordshire OX25 5HD, UK
Biography
Abstract C062: The use of nanoparticles to improve tumour radiosensitivity is one of the research works of Gareth Wakefield. Gareth Wakefield is from Xerion Healthcare Ltd, Cherwell Innovation Centre,UK.
Publications
Research Article Open Access
Nanoparticle Augmented Radiotherapy using Titanium Oxide Nanoparticles
Author(s): Gareth Wakefield, Martin Gardener, Matt Stock and Megan Adair
Titanium oxide is a photoactive material that generates hydroxyl free radicals via water splitting. When doped with rare earth ions titanium oxide nanoparticles are activated by X-rays and X-ray generated electrons and are used to enhance radiotherapy treatment of solid tumours. As the nanoparticles generate free radicals by water splitting the presence of molecular oxygen is not required and aggressive hypoxic tumours may be targeted. A clonogenic assay of radio resistant pancreatic cancer (PANC- 1) cells shows a radiotherapy dose enhancement factor of 1.9 at clinically relevant nanoparticle loadings. A fast growing oropharyngeal cancer (FaDu) xenograft demonstrates that rare earth doped titanium oxide nanoparticles delivered by intratumoural injection disp... view more»
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