Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777

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Gebre-Mariam T Author

tsige.gmariam@aau.edu.et +251 911242095 | +251 9112420

Subjects of specialization
Controlled Drug Delivery, Drug Formulation, Pharmaceutics and Pharmaceutical Technology, Pharmaceutical Formulation, Pharmaceutical Development

Affiliation
Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

Biography

Design, development and optimization of sustained release floating, bioadhesive and swellable matrix tablet of ranitidine hydrochloride are one of the research works of Tsige Gebre-Mariam.

Publications

Research Article Subscription

Fabrication and Evaluation of Cassava Starch Acetate Nanoparticles Loaded with Drugs of Various BCS Classes: Influence of Drug Solubility and Partition Coefficient

Author(s):

Getahun Paulos, Gebre-Mariam T and Neubert HHR

A successful fabrication of nanocarrier for drug delivery should yield nanoparticles (NPs) with suitable particle size and size distribution and provide high drug-loading capacity. Factors that influence these attributes include physicochemical properties of the drug, the nature of the nanocarrier, and processing variables, among others. The aim of this study was, therefore, to investigate the influence of solubility and partition coefficient of different drugs on the characteristics of starch-based NPs. Cassava starch was chemically modified by acetylation, at different degrees of substitution (DS) and characterized. The starch acetates (SAs) were then used for the preparation of drug-loaded NPs. Different model drugs: ibuprofen (BCS class II), acyclovir (B... view more»

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