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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
George Oche Ambrose3 Author
Subjects of specialization
Affiliation
Lung Cancer , Screening Cancer , Biomarkers , Metastasis Cancer , Biology Molecular
Centre for Malaria and other Tropical Diseases, University of Ilorin Teaching Hospital, Kwara State, Nigeria
Biography
George Oche Ambrose is currently working as a Research Officer at Research Officer in the Center for Malaria and other Tropical Diseases UITH (CEMTROD). He is diligent, excellence oriented and highly motivated researcher with high sense of integrity, disciplined andaccustomed to working under pressure. He seek to enhance excellence and growth in an institution to increase its productivity, ability to work effectively in a team, thereby grow in knowledge, skills, professionally, innovation and resourceful.
Publications
Research Article Open Access
Allele Frequency Associated With Dhfr And Dhps Genes Obtained From Plasmodium vivax In Anambara State, Nigeria
Author(s): Isaac Okezie Godwin1 , Ifeoma Mercy Ekejindu1 , George Uchenna Eleje2 , Alfred Friday Ehiaghe1 , Bright Chukwuebuka Unaeze1 and George Oche Ambrose3 *
The Plasmodium vivax dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism. The dhfr and dhps gene mutations are known to be associated with sulphadoxine/ pyrimethamine (SP) resistance. The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with these mutations and to determine their nature and distributions. A total number of 390 pregnant women were recruited, 336 of them were taking SP while 54 of the pregnant women were using other anti-malaria drugs for treatment of malaria. The polymerase chain reaction (PCR) technique was used to characterize the specie of the isolated plasmodium while Sanger sequencing method of molecular genotyping was adopted for the subjection of the ... view more»
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