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Hindi Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777
Getahun Paulos Author
Subjects of specialization
Affiliation
Nanoscience, Nanotubes, Nanomaterials, Nanotechnology, Nanoparticles.
Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
Biography
Getahun Paulos currently works at the Department of Pharmaceutics & Social Pharmacy, Addis Ababa University. Getahun does research in Pharmacy. Getahun Paulos has published one paper regarding "Delivery of Oat-derived Phytoceramides into the Stratum Corneum of the Skin using Nanocarriers: Formulation, Characterization and in vitro and ex-vivo Penetration Studies".
Publications
Research Article Subscription
Fabrication and Evaluation of Cassava Starch Acetate Nanoparticles Loaded with Drugs of Various BCS Classes: Influence of Drug Solubility and Partition Coefficient
Author(s): Getahun Paulos, Gebre-Mariam T and Neubert HHR
A successful fabrication of nanocarrier for drug delivery should yield nanoparticles (NPs) with suitable particle size and size distribution and provide high drug-loading capacity. Factors that influence these attributes include physicochemical properties of the drug, the nature of the nanocarrier, and processing variables, among others. The aim of this study was, therefore, to investigate the influence of solubility and partition coefficient of different drugs on the characteristics of starch-based NPs. Cassava starch was chemically modified by acetylation, at different degrees of substitution (DS) and characterized. The starch acetates (SAs) were then used for the preparation of drug-loaded NPs. Different model drugs: ibuprofen (BCS class II), acyclovir (B... view more»
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