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Hindi Journal of Otology & RhinologyISSN: 2324-8785
Gouml;nuuml;ldaÅ? Burhanettin Author
Subjects of specialization
Affiliation
Recurrent cholesteatoma, Complicated cholesteatoma
Otorhinolaryngology Head and Neck Surgery, Gaziantep University, Gaziantep, Turkey
Biography
I am Gouml;nuuml;ldaÅŸ Burhanettin belonging to the Otorhinolaryngology Head and Neck Surgery, intrested in the field of Recurrent cholesteatoma; Complicated cholesteatoma; Cytokeratin-6; cytokeratin-16; from ?Gaziantep University, Gaziantep, Turkey
Publications
Research Article Open Access
The Importance of Ki-67, Ck-6 and Ck-16 Expression in the Evaluation of the Destructive Effect and Hyper Proliferative Capacity of Cholesteatoma
Author(s): TaÅŸdemir Aykut, GönüldaÅŸ Burhanettin, Erkılıç Suna, Tunç Orhan and Kanlıkama Muzaffer
Objective: Cholesteatoma, with its hyperproliferative feature and destructive pathogenesis, causes bone destruction of the middle ear structures and its surroundings. We aimed to investigate the expression of Ki-67, cytokeratin-6 (CK-6) and cytokeratin-16 (CK-16) in acquired and recurrent cholesteatoma and to correlate them with bone destructive capacity. Materials and Methods: The study was performed as a prospective immunohistochemical study using cholesteatoma tissue (n=45) and external auditory canal skin (n=10) collected during tympanoplasty operation. The findings were recorded considering whether the cholesteatoma was recurrent or not, the extent of cholesteatoma during the operation, ossicular damage and the presence of complications. The patients were divided into 4 groups: Com... view more»
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