Harumi Okuyama | Author | SciTechnol | Endocrinology & Diabetes

Harumi Okuyama Author

harumiokuyama@gmail.com

Subjects of specialization
disease, Religion

Affiliation
Hamamatsu Ika Daigaku, The Jikei University Hospital, Tokyo Dental College Ichikawa General Hospital, University of Western States, Wake Forest University

Biography

Hamamatsu Ika Daigaku, The Jikei University Hospital, Tokyo Dental College Ichikawa General Hospital, University of Western States, Wake Forest University

California Institute of Technology, Hiroshima University, Kanazawa University, Osaka Prefecture University, University of Houston

Publications

Review Article Open Access

Statins Cause Lifestyle-Related Diseases-Biochemical Mechanism

Author(s):

Yoko Hashimoto and Harumi Okuyama

While statins are being used worldwide for the prevention of cardiovascular diseases, statin users have an increased probability of developing diabetes, arteriosclerosis, and other lifestyle-related diseases. Here, we review the molecular mechanisms underlying the onset of osteoporosis, chronic kidney disease, type 2 diabetes, and arteriosclerosis, and lowered testosterone levels induced by statin use. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which is a rate-limiting enzyme of the mevalonate pathway that generates geranylgeranyl diphosphate (GGPP), 7-dehydrocholesterol (7-DHC), and cholesterol. GGPP is essential for vitamin K2 (VK2) synthesis from ingested vitamin K1. 7-DHC is a precursor of vitamin D3 (VD3). VD3 and VK2 upr... view more»

DOI: 10.4172/2470-7570.1000122

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