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Hindi La Prensa MedicaISSN: 0032-745X
Hayder Al-Aubaidy Author
Subjects of specialization
Affiliation
ADRB1 polymorphism , Metoprolol, Acute coronary syndrome
School of Life Sciences, College of Science, Health and Engineering, La Trobe University, Bundoora, VIC, Australia
Biography
Hayder Al-Aubaidy, belonging to the School of Life Sciences, intrested in the field of ADRB1 polymorphism; Metoprolol; Acute coronary syndrome ?from College of Science, Health and Engineering, La Trobe University, Bundoora, VIC, Australia
Publications
Research Article Open Access
A Comparative Study to illustrate the Effects of Beta-1 Adrenergic Receptor Allelic Polymorphism on Disease Outcome in Iraqi Patients with Acute Coronary Syndrome (on Metoprolol Therapy)
Author(s): Asma A Swadi, Bassim I Mohammad, Najah R Hadi and Hayder Al-Aubaidy
Objective: The response to metoprolol therapy in patients with acute coronary syndrome (ACS) is variable and a substantial element of this variability is linked to variation in CYP2D6 enzyme and adrenoreceptor (ADRB1) alleles, genotype polymorphism, affecting the phenotype in terms of both rate of metabolism of the active metoprolol (and hence its metabolic ratio) and the responsiveness of ADRB1 receptors to bound metoprolol. This study aims to investigate different clinically relevant allele variants (allele frequencies) of ADRB1 genes: (Arg389Gly: Gly/Gly, Gly/Arg, Arg/Gly) and to determine whether a specific genotype of Beta-1 adrenergic receptor genes (based on genetic polymorphism "allelic types" and combination) have impact on metoprolol effectiveness (clinical outcome) in Arabic ... view more»
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