Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Hitoshi Tsuda Author

Yoshida.Yuichiro@sysmex.co.jp

Subjects of specialization
Mucoepidermoid carcinoma, Cancer chemotherapy, Prostate biomarker, Endometrial cancer

Affiliation
Pathology, National Defense Medical College, Saitama, Japan

Biography

Hitoshi Tsuda was working in the Pathology, National Defense Medical College, Saitama, Japan. Doctor has more than 40 publications. Doctor's current research area related to osteoarthropathy. Doctor was specialised in Endometrial cancer. 

Publications

Research Article Open Access

Prognostic Model of Stage II/III Colon Cancer Constructed using Gene Expression Subtypes and KRAS Mutation Status

Author(s):

Kengo Gotoh#, Eiji Shinto#, Yuichiro Yoshida*, Hideki Ueno,Yoshiki Kajiwara, Masato Yamadera, Ken Nagata, Hitoshi Tsuda, Junji Yamamoto and Kazuo Hase

Objectives: Cancer subtypes classified according to DNA microarray data predict prognosis with high accuracy. Here we constructed a new colon cancer (CC) subtype classification based on only of genes with known biological functions with the aim of establishing a new prognostic model for clinical use.

Methods: We performed an expression correlation analysis using data for 73 primary CC cases in the public dataset (learning set), focusing on genes located on the long arms of chromosomes 18 and 20 and stromal-related genes. We determined the representation of each gene in the modules with closely correlated expression levels in the same module. Mutations in KRAS, BRAF and TP53 were assessed ... view more»

DOI: 10.4172/2324-9110.1000214

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