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Hindi La Prensa MedicaISSN: 0032-745X
Hussam H Sahib Author
Subjects of specialization
Affiliation
Leukotriene inhibitors MK-886, Zileuton, Doxorubicin (DX)-induced acute kidney damage, Urea, Dysfunctional kidneys
College of Pharmacy, University of Al-Qadisiyah, Iraq
Biography
Hussam H Sahib, belonging to College of Pharmacy, interested in the field of Leukotriene inhibitors MK-886; Zileuton; Doxorubicin (DX)-induced acute kidney damage; Dysfunctional kidneys; Creatinine; Urea; Acute renal failure ?from University of Al-Qadisiyah, Iraq
Publications
Research Article Open Access
Comparative Protective Effect of Zileuton and MK-886 against Acute Kidney Injury Induced by Doxorubicin
Author(s): Ahmed M Sultan, Hussam H Sahib, Hussein A Saheb and Bassim I Mohammad
Objective: To determine the protective effects of the leukotriene inhibitors MK-886 and Zileuton on doxorubicin (DX)-induced acute kidney damage in a rat model. Methods: A rat model of acute kidney injury (AKI) was established by a 3-day regimen of DX. The animals were suitably treated with MK-866 or Zileuton, and untreated DX injected and healthy controls were also included. The rat sera were analyzed for the levels of creatinine and urea as markers of renal injury and for the levels of the oxidative stress markers GSH and MDA using standard assays. In addition, the renal tissues of the rats were processed and histo-pathologically analyzed by HE staining. Results: DX injection significantly increased the levels of creatinine and urea, indicating dysfunctional kidneys. The levels of bot... view more»
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