Ikuo Konishi Author

Review Article Open Access

A diagnostic biomarker: differential expression of LMP2/β1i in human uterine neoplasms

Author(s):

Takuma Hayashi, Akiko Horiuch, Kenji Sano, Nobuyoshi Hiraoka, Tomoyuki Ichimura, Osamu Ishiko, Yae Kanai, Nobuo Yaegashi, Tanri Shiozawa, Hiroyuki Aburatani, Susumu Tonegawa and Ikuo Konishi

Uterine leiomyosarcoma (Ut-LMS) more frequently develops in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecological tumors is often correlated with the secretion of female hormones; however, the development of Ut-LMS has not been correlated with hormonal conditions, and risk factors remain unknown. A diagnostic biomarker that can distinguish malignant Ut-LMS from benign tumor leiomyoma (LMA) has not yet been established. Therefore, an analysis of the risk factors associated with human Ut-LMS is needed in order to establish a treatment method. Proteasome LMP2/... view more»

DOI: 10.4172/2324-9110.1000128

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