Jacques Chiaroni Author

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De Novo Persistent Post-Lung Transplantation HLA Donor-Specific Antibodies (DSA) but not Preformed DSA are Associated with Worse Survival and a Higher Risk of Developing Chronic Lung Allograft Dysfunction

Author(s):

Christophe Picard, Agnès Basire, Anderson Loundou, Matthieu Pelardy, Jacques Chiaroni, Pascal Thomas, Carine Gomez and Martine Reynaud-Gaubert

Background: The introduction of highly sensitive solid-phase immunoassay technology permitted better detection and characterization of donor-specific HLA antibodies (DSA) in pre- and post-transplant period; however their impact on clinical outcome after lung transplantation (LTx) remains controversial. Patients and methods: A retrospective analysis on a cohort of 138 adult recipients who had undergone LTx at the Marseille Lung Transplant Centre (France) between 1998 and 2010 was performed. Detection at Day 0, Month 1, Month 3,Month 12 and Month 24 post- LTx of HLA antibodies (Abs) and DSA was investigated using a Luminex assay. Results: Pre-LTx DSA (n=15) were not correlated to overall survival and development of CLAD. De novo DSA were frequently detected (41% of cases), appeared earlie... view more»

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