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Hindi Clinical Oncology: Case Reports
James Clune Author
Subjects of specialization
Affiliation
cancer, cancer oncology
Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
Biography
James Clune is an Assistant Professor of Surgery, Plastic and Reconstructive Surgery at the Yale School of Medicine. Dr. Clune specializes in reconstruction of melanoma and sarcoma defects of the face/scalp, and procedures that treat tumors of the upper extremity, brachial plexus tumors, brachial plexus reconstruction, pediatric hand anomalies, peripheral nerves. Research interests include targeted muscle reinnervation after tumor extirpation or amputation and isolated limb perfusion of the extremities for soft tissue tumors
Publications
Case Report Open Access
Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors
Author(s): Ana Luisa Perdigoto, Thuy Tran, Natalie Patel, Pamela Clark, Kanchi Patell, Angeliki M Stamatouli, Vikram Reddy, James Clune, Kevan C Herold, Marie E Robert and Harriet M Kluger
Checkpoint inhibitor immunotherapy has significantly advanced treatment of a growing number of advanced malignancies. A consequences of immune system activation that leads to tumor cell destruction by checkpoint inhibitor therapy is the development of immune-related adverse events, some of which can be life threatening. There are limited data on the use of checkpoint inhibitor therapy in patients with preexisting autoimmunity owing to concerns that underlying autoimmune disease may be exacerbated by checkpoint inhibitor treatment. Decisions to treat these patients are made after careful consideration of the risks and benefits of treatment. We describe a patient with active and severe ulcerative colitis with metastatic melanoma who underwent elective cole... view more»
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