Journal of Obesity and Therapeutics

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James E Trosko Author

trosko@msu.edu

Subjects of specialization
Cancer Biology, Mutation

Affiliation
Department of Pediatrics/Human Development, Michigan State University, East Lansing.

Biography

Dr. James E Trosko, is currently working in the Department of Pediatrics/Human Development, Michigan State University, East Lansing. His research interests include Mutation, Signal Transduction, Cancer Biology etc.,

Publications

Editorial Open Access

Obesity 2018: What roles do colon stem cells and gap junctions play in the left and right location of origin of colorectal cancers?- James E Trosko- Kermanshah University of Medical Sciences, Iran

Author(s): James E Trosko

This "Comment" examines an important clinical observation that colorectal cancers on the right side appear less treatable than cancers on the left side. The concepts of (a) the "initiation / promotion / progression" process, (b) the stem cell hypothesis, (c) the role gap in intercellular binding communication, (d) cancer cells lacking GJIC due to non-expression of connexin genes or non-functional gap junction proteins, and (e) the role of the microbiome in promoting colon stem cells initiated to divide symmetrically or asymmetrically is examined for an explanation. It has been speculated that "embryonic-type" lesions in the ascending colon are initiated stem cells, promoted by symmetric cell division, whereas polyp-type lesions in the descending colon are initiated stem cells stimulated ... view more»

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