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Hindi Journal of Virology & Antiviral ResearchISSN: 2324-8955
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Jay C Brown Author
Subjects of specialization
Affiliation
Herpes Simplex Virus Capsid, Microbiology,, Immunology, Cancer Biology
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Biography
Jay C Brown is a Professor of Microbiology, Immunology, and Cancer Biology at University of Virginia Cancer Center, USA . He obtained his BA in Johns Hopkins University, Baltimore.He was awarded the Ph.D. at Harvard University, Cambridge, USA. Brown was a post-doctoral fellow at MRC Lab of Molecular Biology, Cambridge UK. His major research interests focus on Structure and Assembly of the Herpes Simplex Virus Capsid. The Brown lab studies herpesvirus infections that affect cancer patients with emphasis on HSV-1 and KSHV.
Publications
Research Article Open Access
DNA Zip Codes in Herpesvirus Genomes
Author(s): Jay C Brown
The genomes of 39 herpesviruses were examined for the presence of DNA zip codes, sequence elements found in yeast to be involved in gene localization to the nuclear periphery and transcriptional memory. Tests were carried out with three different zip codes and with viruses in all three subfamilies of the Herpesviridae. All genomes were found to have have at least three zip codes with 30 the most observed. Zip codes in many alphaherpesviruses and in human cytomegalovirus were found to be symmetrically arrang... view more»
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