Journal of Virology & Antiviral ResearchISSN: 2324-8955

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Jay C Brown Author

jcb2g@virginia.edu 434-924-1814

Subjects of specialization
Herpes Simplex Virus Capsid, Microbiology,, Immunology, Cancer Biology

Affiliation
Department of Microbiology, Immunology, and Cancer Biology, University of Virginia Health System, Charlottesville, Virginia 22908, USA

Biography

Jay C Brown is a Professor of Microbiology, Immunology, and Cancer Biology at University of Virginia Cancer Center, USA . He obtained his BA in Johns Hopkins University, Baltimore.He was awarded the Ph.D. at Harvard University, Cambridge, USA.  Brown was a post-doctoral fellow at MRC Lab of Molecular Biology, Cambridge UK. His major research interests focus on Structure and Assembly of the Herpes Simplex Virus Capsid. The Brown lab studies herpesvirus infections that affect cancer patients with emphasis on HSV-1 and KSHV. 

Publications

Review Article Subscription

Role of Coatomer Protein I in Virus Replication

Author(s): Jennifer A Thompson and Jay C Brown

Role of Coatomer Protein I in Virus Replication

Coatomer protein I (COPI) is well known as the protein coat surrounding vesicles involved in returning endoplasmic reticulum (ER)-resident proteins to the ER. COPI coats are also found in vesicles involved in other trafficking processes including endocytosis, autophagy and anterograde transport in the secretory pathway. In view of the diverse functions of COPI proteins, it is expected that they will affect virus replication, and many reports of such COPI involvement have now appeared. The experimental approaches most often employ specific siRNA to deplete COPI subunits or brefeldin A to block COPI activation.

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DOI: 10.4172/2324-8955.1000102

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