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Hindi Journal of Nanomaterials & Molecular NanotechnologyISSN: 2324-8777
Jens Hartmann Author
Subjects of specialization
Affiliation
Biomedical Technology
Danube University Krems, Center for Biomedical Technology, Dr.-Karl-Dorrek Str. 30, 3500 Krems, Austria
Biography
Jens Hartmann is affiliated with the Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, Althanstraße 14, 1090 Vienna, Austria. Jens Hartmann has a specialization in the field of Biomedical Technology.
Publications
Research Article Open Access
Polymyxin-Coated Nanostructured Materials: An Option for Sepsis Treatment
Author(s): Stephan Harm and Jens Hartmann
Polymyxin-Coated Nanostructured Materials: An Option for Sepsis Treatment
Objective:
Endotoxins (lipopolysaccharides, LPS) are among the main targets in extracorporeal therapies. LPS, which is the major component of the outer cell wall of Gram-negative bacteria, strongly induces inflammatory responses in humans at concentrations lower than 1 ng/kg body weight. Although the elimination of LPS is promising for the supportive therapy of sepsis and liver failure, endotoxin neutralization using endotoxin adsorbents is controversial. Earlier studies show that Polymyxin B (PMB) could be applied for endotoxin inactivation in blood. Aim of this study was to establish an adsorbent-based PMB rel... view more»
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