John J Kim | Author | SciTechnol | Cell Biology: Research & Ther

John J Kim Author

johnjkim@jhmi.edu (510) 642-5835 | (510) 642-58

Subjects of specialization
Bioengineering,Bio-Chemistry,Bioenergy,Diagnostics,Medicine

Affiliation
San Francisco Graduate Program in Bioengineering, USA

Biography

John J Kim is Works in the University of California, Berkeley and University of California, San Francisco Graduate Program in Bioengineering, USA. Chemotherapy Increases Aggressiveness of Prostate Cancer via Epithelial Mesenchymal Transition

Publications

Short Communication Subscription

Chemotherapy Increases Aggressiveness of Prostate Cancer via Epithelial Mesenchymal Transition

Author(s):

John J Kim, James E Verdone and Steven M Mooney

Chemotherapy Increases Aggressiveness of Prostate Cancer via Epithelial Mesenchymal Transition

Although chemotherapy has been used as a major therapeutic weapon against advanced prostate cancer, overcoming drug resistance is still a major challenge. Cancer has been known to diminish therapeutic effect by several molecular mechanisms– increasing efflux by recruiting cell membrane pumps and limiting drug diffusion by constructing leaky vasculature. Moreover, recent studies suggest that long-term treatment with chemotherapy may have detrimental effects for patients presenting with solid tumors. Specifically, prostate cancer epithelial cells develop resistance t... view more»

DOI: 10.4172/2324-9293.1000105

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