Juan F. Santibanez Author
Subjects of specialization
Affiliation
Cellular Immunology,Cellular Pathology,Cell Tissue Studies,Stem Cells,Medicine
Laboratory for Experimental Hematology and Stem Cells
Juan F. Santibanez works Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, Dr Suboti?a 4, 11129 Belgrade, Serbia. He has international experience on various programs, and also contributed and participated in different countries for diverse fields of study. Research interests reflect in wide range of publications in various national and international journals.
Special Issue Article Subscription
Author(s): Jelena Krstic and Juan F. Santibanez
Transforming Growth Factor-Beta and Matrix Metalloproteinases Functional Interplay in Cancer; Implications in Epithelial to Mesenchymal Transition
Transforming growth factor beta (TGF-β), a pleiotropic factor with several different roles in health and disease, has been shown to act differently during tumorigenesis, depending on the stage of tumor progression. In the early stages, TGF-β acts as a tumor suppressing factor, while in advanced stages of tumor it acts as a tumor promoting factor. One of the hallmarks of tumor progression is the capacity of cancer cells to migrate and invade surrounding tissues with subsequent metastasis to different organs. The... view moreĀ»