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Hindi Journal of Immunological Techniques & Infectious Diseases ISSN: 2329-9541
Jumani RS Author
Subjects of specialization
Affiliation
Mycobacterium tuberculosis; Rv3881c; Human polyfunctional T cells; Guinea pig model; Experimental vaccine
Department of Microbiology and Cell Biology, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore, Karnataka 560012, India
Biography
Dr. Jumani RS was an Assistant Professor of Department of Microbiology and Cell Biology, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore, Karnataka 560012, India, and later he started working on Rv3881c from Mycobacterium tuberculosis Elicits PolyFunctional CD8+ T cells in PPD Positive Healthy Volunteers and Affords Significant Protection in the Guinea Pig Model
Publications
Research Article Subscription
Rv3881c from Mycobacterium tuberculosis Elicits PolyFunctional CD8+ T cells in PPD Positive Healthy Volunteers and Affords Significant Protection in the Guinea Pig Model
Author(s): Satchidanandam V, Kumar N , Biswas S, Jumani RS, Jain C, Rani R, Aggarwal B, Singh J, Kotnur MR, Challu V, Chadha VK, Kumar P and Sridharan A
We show that Rv3881c, a secreted protein of M. tuberculosis (MTB), elicits T cell responses from healthy PPD-positive individuals and TB patients. Synthetic peptides spanning the complete length of Rv3881c induced secretion of significantly greater levels of TNF-α and IL-10 from peripheral blood mononuclear cells of TB patients compared to latently infect healthy volunteers. Polychromatic flow cytometry detected poly-functional CD4+ and CD8+ T cells secreting different combinations of IFN-γ, TNF-α, IL-2 and MIP-1β in response to Rv3881c. Lev... view more»
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