Kathiravan K Author

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Chitosan Nanoparticles as a Potential Drug Delivery System for Photodynamic Therapy of Cancer

Author(s):

Amsaveni G, Sakthivel M, Kathiravan K, Anish B and Murugesan R

Objective: Chitosan nanoparticles (CS-NP) can imbibe water insoluble anticancer agents into its hydrophobic multicores. In the present study, chitosan nanoparticles, a nanoscale drug carrier system is investigated for its potential as a drug delivery system for porphyrin based photodynamic therapy. Methods: Zinc meso tetra phenyl porphyrin (ZnmTPP) encapsulated CS-NP was prepared by ionic gelation method. The synthesized nanoparticles were characterized using dynamic light scattering studies, zeta potential analysis and AFM analysis. Results: Freshly prepared chitosan nanoparticles had an average hydrodynamic diameter of 175 nm and are nearly spherical in shape as per light scattering measurements and atomic force imaging respectively. As nanoscale drug carriers, (ZnmTPP) encapsulated c... view more»

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