Kavitha M Author

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The 'Giant Danio' (Devario aequipinnatus) - Another Model for Diabetic Retinopathy Study: Induction of Hyperglycemia and Resultant Retinal Impairments

Author(s):

Raja M, Kavitha M, Ramkumar R, Anandhi M and Perumal P

Background: To develop the Giant Danio, Devario aequipinnatus as a model animal to examine the type 1 diabetes associated vision impairment that occurs in human.
Methods: The induction of hyperglycemia in Giant Danio by alternately immersing the fish in glucose solution and water. Eyes from untreated fish as well as fish exposed to alternating 1% and 2% glucose/water solutions for 15 and 13 days were dissected, sectioned, stained and then visualized for their retinal morphology and the thickness of retinal layers we... view more»

DOI: 10.4172/2470-7570.1000108

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