Clinical Oncology: Case Reports

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Kevan C Herold Author

kevan.herold@yale.edu

Subjects of specialization
cancer, cancer oncology

Affiliation
Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Immunobiology, Yale University, New Haven, Connecticut, USA

Biography

His focus has largely been in the field of autoimmune Type 1 diabetes. The work encompasses basic laboratory work as well as clinical studies to understanding the regulation of autoreactive T cells to clinical trials that involve novel therapeutics. As part of these studies He have also been very interested in analysis of beta cell function in Type 1 diabetes. His clinical and basic studies are focused on understanding how beta cells are destroyed and react to inflammation.

Publications

Case Report Open Access

Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors

Author(s):

Ana Luisa Perdigoto, Thuy Tran, Natalie Patel, Pamela Clark, Kanchi Patell, Angeliki M Stamatouli, Vikram Reddy, James Clune, Kevan C Herold, Marie E Robert and Harriet M Kluger

Checkpoint inhibitor immunotherapy has significantly advanced treatment of a growing number of advanced malignancies. A consequences of immune system activation that leads to tumor cell destruction by checkpoint inhibitor therapy is the development of immune-related adverse events, some of which can be life threatening. There are limited data on the use of checkpoint inhibitor therapy in patients with preexisting autoimmunity owing to concerns that underlying autoimmune disease may be exacerbated by checkpoint inhibitor treatment. Decisions to treat these patients are made after careful consideration of the risks and benefits of treatment. We describe a patient with active and severe ulcerative colitis with metastatic melanoma who underwent elective cole... view more»

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