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Hindi Clinical Oncology: Case Reports
Kuey-Chu Chen Author
Subjects of specialization
Affiliation
Gene duplication, DNA sequencing, Biology, Gene expression in aging brain and stress
Research Associate Professor, Director of the Microarray Core Facility,
Biography
Dr. Kuey-Chu Chen is a Research Associate Professor Director of the Microarray Core Facility, and complete her Phd in Genetics. University of California, Davis. Research activities involve studies of gene expression in brain in relation to aging and hormone regulation. Research approaches emphasize the use of molecular biology, particularly quantitative analysis of messenger RNA in the brain, to investigate the expression of certain genes
Publications
Case Report Subscription
A Case Study of Precision Medicine: Next Generation Sequencing Compared with Oncoscan in a Patient with Breast Cancer in Kentucky
Author(s): Rolf J Craven*, Kuey-Chu Chen, Steven Schwarze, Sydney Lay, Dana Napier and Rachel Stewart
Purpose: Precision medicine of tumors is designed to tailor treatment combinations to individual patients, targeting specific genotypes with corresponding inhibitors. The purpose of this study was to determine whether genotype predicted target gene expression-a critical parameter for treatment-and to test whether alternate modes of gene amplification could affect gene expression. Patients and methods: The cohort consisted of patients in Kentucky with recurrent breast cancer who were analyzed by nextgeneration sequencing. Tumors with amplifications in CCND1, AURKA, and MYC were then stained by immunohistochemistry. We subsequently selected a patient with triple-negative breast cancer for analysis by FISH, immunohistochemistry and OncoScan genome-wide copy number array. Results: The exten... view more»
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