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Kurilin V Author
Subjects of specialization
Affiliation
Arthritic conditions, Bursa inflammation (Bursitis), Fibrositis (Fibromyalgia syndrome), Fractures, Kyphosis
Novosibirsk State University, Russia. Research Institute of Fundamental
Biography
Dr. Verghese Kurien was born on November 26, 1921 to an affluent Syrian Christian family in Calicut (now Kozhikode), Kerala. His father Puthenparakkal Kurien was a civil surgeon in British Cochin and his mother was a highly educated woman as well an exceptional piano player. He was named after his uncle Rao Sahib P.K Verghese. Dr Kurien joined Loyola College in Madras and attained his degree in B.Sc in Physics.
Publications
Short Communication Open Access
Dendritic cells expressing MHC epitopes reduce allo-reactivity in vitro
Author(s): Valeriy Tereshchenko, Kurilin V, Shevchenko J, Maksyutov A and Sennikov S
Although immunosuppressive therapy of graft rejection and graft-versus-host disease significantly increases the chance of successful allograft survival, it is often accompanied by severe side effects such as opportunistic infections and cancers. Therefore, the development of biological approaches to induce antigen-specific immunological tolerance to transplanted organs and tissues might be promising. In this study, C57Bl/6 mice dendritic cells (DCs) transfected with CBA mice MHC epitopes to suppress alloantigen-induced immune response in vitro were used. It was found that C57Bl/6 DCs transfected with CBA mice MHC epitopes were capable to induce FoxP3+ Tregs and IL-10+CD4+ cells in autologous splenocyte cultures. Also, C57Bl/6 DCs transfected with CBA mice MHC epitopes suppressed the pro... view more»
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