Lakshmi Vasudha Yerrinki Author

Research Article Open Access

Screening and Identification of Antiviral Drugs from Drug Bank Database Targeting SARSCov- 2 Non-Structural Proteins (NSP): A Virtual Screening and Molecular Docking Study

Author(s):

Alam MM*, Shill DK, Jahan S, Alam M, Hossain ME, Rahman M and Rahman MZ

The ongoing pandemic of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) is a positive-sense RNA (ss) virus. Mutational change is a typical episode resulting in their emerging regional variants not responding to the vaccine equally. Therefore, along with vaccines, antiviral drugs targeting non-structural proteins (nsp) can be a remedy to provide maximum protection. Moreover, in immune compromised individuals, antiviral drugs can be the only reliable choice to tackle these types of infections. Here, nonstructural proteins (nsp) named RNA dependent RNA polymerase (RdRp), Helicase (NSP13), and Papain-like Protease (NSP3) were selected as the target for drugs that can provide protection irrespective of mutational variants. Validated structures of these three essential proteins ... view more»

Abstract HTML PDF