Leonor Fernandes Author

Research Article Open Access

Pancreatic Cancer AssociatedCachexia: Role of the Modified Glasgow Prognostic Score in Outcome Prediction

Author(s):

Debora Cardoso, Leonor Vasconcelos Matos, Leonor Fernandes, Tiago Dias Domingues, Ricardo João, Renata Medeiros-Mirra, Helena Miranda and Ana Martins

Cancer-associated-cachexia (CAC) is a ubiquitous characteristic of pancreatic cancer (PC) and 1/3 of patients die from its complications. Systemic inflammation is key in CAC and the modified Glasgow Prognostic Score (mGPS) is a reliable inflammation-based prognostic tool. We aimed to evaluate the prognostic value of consensus-based cachexia classification and mGPS, their agreement and to analyze relevant clinical predictors of cachexia. This unicentric, retrospective, cohort study included patients with advanced PC treated over a 5-year period. Cachexia was classified according to weight loss, body mass index and mGPS. Fisher’s test was used to test correlation between classifications and logistic regression models were performed to test their association with other variables. Sur... view more»

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