Advanced Biomedical Research and Innovation

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Libo Yu Author

Libo897@cu.hk

Subjects of specialization
Applied Microbiology, Applied Microscopy, Applied Mycology, Applied Physiology, Biomedical Research

Affiliation
The Chinese University of Hong Kong, Hong Kong

Biography

Libo Yu is a PhD student in the School of Biomedical Sciences, The Chinese University of Hong Kong. She has completed her master’s studies on exosome mediated tumour metastasis in the Chinese Academy of Sciences in 2017. At present her research interest focuses on the differentiation of mesenchymal stem cell and related cell signalling pathways.

Publications

Short Communication Open Access

Depletion of TM9SF4 promotes osteogenic differentiation of mesenchymal stem cells

Author(s):

Libo Yu and Xiaoqiang Yao

Cytoskeleton reorganization is a critical factor of mesenchymal stem cell (MSC) differentiation. The change of cytoskeleton is closely related with mechanical stress signals, which participate in MSCs lineage commitment. Usually, spread and flatten MSCs will undergo osteogenesis, while round cells will turn into adipocytes. Trans-membrane 9 superfamily member 4 (TM9SF4) belongs to the trans-membrane 9 superfamily and involves in phagocytosis in Dictyostelium discoideum and Drosophila. The lab has previously found that TM9SF4 can induce actin S-glutathionylation on Cys374, which leads to the de-polymerization of actin fibres and change the cytoskeleton.

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