Lo PK Author

Review Article Open Access

Emerging Techniques in Single-Cell Epigenomics and their Applications to Cancer Research

Author(s):

Lo PK and Zhou Q

Epigenomics encompasses studies of the chemical modifications of genomic DNA and associated histones, interactions between genomic DNA sequences and proteins, the dynamics of the chromosomal conformation, the functional relationships between these epigenetic events, and the regulatory impacts of these epigenetic events on gene expression in cells. In comparison to current techniques that are only capable of characterizing average epigenomics features across bulk cell ensembles, singlecell epigenomics methodologies are emerging as powerful new techniques to study cellular plasticity and heterogeneity, as seen in stem cells and cancer. Here we summarize available techniques for studies of single-cell epigenomics, review their current applications to cancer research, and discuss future pos... view more»

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