Advanced Biomedical Research and Innovation

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M Heggeness Author

Subjects of specialization
Applied Microbiology, Applied Microscopy, Applied Mycology, Applied Physiology, Biomedical Research

Affiliation
University of Kansas School of Medicine, USA

Biography

M Heggeness, completed his PhD at UC San Diego in membrane biology, and a postdoc at Rockefeller University in Virology. He received his MD from the University of Miami. After a residency in Orthopaedic Surgery, he was completing a fellowship in Spine Surgery at the University of Toronto. He then joined the faculty at Baylor College of Medicine where he became Chairman of Orthopaedic Surgery in 2004. He moved take the Orthopaedic Surgery Chair at University of Kansas in Wichita in 2013. He has 84 publications and 4 issued patents.


Publications

Short Communication Open Access

Quiescent pluripotent stem cells reside within murine peripheral nerves and can be stimulated to proliferate by rhBMP2 or by nerve trauma

Author(s):

M Heggeness and S Y Yang

A novel and distinct newly discovered source of pluripotent stem cells obtainable from the peripheral nerves of mouse, rat and human that are believed to solve the most vexing problems presently hampering efforts to apply the use of use of stem cells to safe and effective clinical treatments will be described. A large population of quiescent cells within peripheral nerves which in response to nerve injury or stimulation with the cytokine BMP2, proliferate and generate populations of pluripotent stem cells has been documented. The cells express Sox2, Klf4, Oct4 and c-Myc, the four transcription factors that confer embryonic pluripotency, as verified by double stain immunohistochemistry and by real time PCR.

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Abstract PDF



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