Mailk Abdin | Author | SciTechnol | Journal of Pharmaceutical Sc

Mailk Abdin Author

aparna_jadhav@urdip.res.in

Subjects of specialization
Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Drag reduction, Drug Therapy

Affiliation
Department of Biotechnology, Faculty of Science, Jamia Hamdard, New Delhi- 110062, India

Biography

Mailk Abdin; Department of Biotechnology, Faculty of Science, Jamia Hamdard, New Delhi- 110062, India. Keywords: Adverse Drug Reactions,Drug Action,Drug Delivery,Drug Discovery,Drug interaction,Drug Intoxication,Drug Therapy; Drug Transport and Delivery, Emerging Drugs, Medicinal Chemistry, Pharmaceutical Analysis, Pharmaceutical Design, Pharmaceutical Sciences, Pharmaceutics and Drug Design, Pharmacoepidemiological Studies, Pharmacognosy, Pharmacology

Publications

Research Article Subscription

Structure Based Docking of Small Hirudin like Peptides with Thrombin

Author(s):

Aparna Jadhav, RadhaCharan Dash, Raj Hirwani and Mailk Abdin

Hirudin variant like small peptide or peptidomemitic compounds are known to inhibit thrombin. These 10 to 20 amino acid long molecules are reported to primarily bind at exosite 1 of thrombin. To know more about their interaction with thrombin, initially we docked 5 different hirudin variant peptides having 10 to 13 aa sequences. It helped to identify single best docking peptide (12 aa sequence) i.e. GDFEEIPEEYLQ (pdb: 1FPH _I chain) with docking score -3.42 kcal/Mol, amongst the set of peptides. This peptide was further truncated to form a series of peptides having 7 to 12 aa sequence range. The truncated peptides were further docked at thrombin exosite 1 binding site. Amongst these the best docking 7 aa peptide i.e. GDFEEIP, with docking score -4.43 kcal/Mol was identified. This experi... view more»

DOI: 10.4172/2380-9477.1000116

Abstract HTML PDF