Manal Baddour Author

Review Article Open Access

Broadly Neutralizing Antibodies between HIV Vaccination and Treatment the Beginning of the End?

Author(s):

Mohannad Naser, Hebatullah Hassan, Nada Hisham and Manal Baddour*

For many years, HIV has been a major concern for both health professionals and researchers. Some of the HIV infected individuals develop broadly neutralizing antibodies (bNAbs). Different studies have shown that these bNAbs can be used in HIV prevention and treatment. BNAbs mostly act on four main sites (sites of vulnerability) on the viral spike of the conserved epitope known as CD4-Binding Site, First and Second Variable Domains (V1/V2) of the Env trimer, Third Variable Domain (V3)/Oligomannose Glycan Patch Involving Asn332 Glycan and Membrane Proximal External Region (MPER). Reverse vaccinology is considered a different concept of HIV prevention through figuring out the structure of bNmAbs. Although several trials were done in the field of HIV vaccination... view more»

DOI: 10.4172/2324-8955.1000183

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