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Marie E Robert Author
Subjects of specialization
Affiliation
Immunotherapy; Checkpoint; Inflammatory bowel disease; Colitis; Complications
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
Biography
Dr. Marie E Robert is working in the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA. His specialization in the field of Immunotherapy; Checkpoint; Inflammatory bowel disease; Colitis; Complications
Publications
Case Report Open Access
Elective Colectomy in a Patient with Active Ulcerative Colitis and Metastatic Melanoma Enabling Successful Treatment with Immune Checkpoint Inhibitors
Author(s): Ana Luisa Perdigoto, Thuy Tran, Natalie Patel, Pamela Clark, Kanchi Patell, Angeliki M Stamatouli, Vikram Reddy, James Clune, Kevan C Herold, Marie E Robert and Harriet M Kluger
Checkpoint inhibitor immunotherapy has significantly advanced treatment of a growing number of advanced malignancies. A consequences of immune system activation that leads to tumor cell destruction by checkpoint inhibitor therapy is the development of immune-related adverse events, some of which can be life threatening. There are limited data on the use of checkpoint inhibitor therapy in patients with preexisting autoimmunity owing to concerns that underlying autoimmune disease may be exacerbated by checkpoint inhibitor treatment. Decisions to treat these patients are made after careful consideration of the risks and benefits of treatment. We describe a patient with active and severe ulcerative colitis with metastatic melanoma who underwent elective cole... view more»
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