Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604

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Marilena Vlachou Author

vlachou@pharm.uoa.gr

Subjects of specialization
Melatonin; Controlled release; Experimental design; Formulation; Matrix tablets

Affiliation
Department of Pharmacy, National and Kapodistrian, Department of Pharmacy, Division of Pharmaceutical Technology, Panepistimioupoli-Zografou, 84 Athens, Greece

Biography

Marilena Vlachou Department of Pharmacy, National and Kapodistrian, Department of Pharmacy, Division of Pharmaceutical Technology, Panepistimioupoli-Zografou, 84 Athens, Greece

Publications

Research Article Open Access

Optimization of Controlled Release Matrix Formulations of the Chronobiotic Hormone Melatonin via Experimental Design

Author(s):

Marilena Vlachou, Angeliki Siamidi, Sofia Konstantinidou and Yannis Dotsikas

Melatonin (MT) is a chronobiotic hormone synthesized by the pineal gland and has a significant role in the regulation of the circadian biological clock. In order to be administered as a drug, the time of melatonin release from its formulation is of great significance. To this purpose, controlled release matrix tablets (200 mg) of MT were developed by using D-optimal experimental design, including 1 categorical and 2 numerical factors, aiming at effecting its sustained release using a USP XXIII dissolution apparatus II at pH 1.2 and 7.4 media. The excipients selected are polyvinyl pyrrolidone (M.W.: 10.000 and 55.000), hydroxylpropyl Methylcellulose K15M and lactose monohydrate. The in vitro release data were fitted to the Korsmeyer-Peppas empirical equation;... view more»

DOI: 10.4172/2325-9604.1000159

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