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Hindi Journal of Clinical & Experimental OncologyISSN: 2324-9110
Martin Ezeani Author
Subjects of specialization
Affiliation
Glycolysis, Oxidative phosphorylation, Cancer progression, Treatment resistance, Autophagy
Department of Neurosciences, University of Sussex, United Kingdom
Biography
Martin Ezeani was working at Department of Neurosciences, University of Sussex, United Kingdom. he ahs more than 50 publications. His current research area related to cancre progressions.
Publications
Review Article Subscription
Metabolic Basis of Treatment Failures; Autophagy and Malignant Cancer Progression
Author(s): Maxwell Omabe1, Martin Ezeani and Ugoeze Donatus
Cells use a number of pathways to generate energy and synthesize cellular building blocks including lipids, carbohydrates and nucleotides. Alterations in metabolic pathways have been implicated in many pathophysiological conditions. This mechanism is exploited by both resident epithelial cancer cells and the fibroblast. Indeed, cancer and normal cells differ dramatically in terms of their energy requirements and use of metabolic pathways. Mitochondrial dysfunction and metabolic impairment contribute immensely to chemotherapeutic resistance and metastatic cancer progression through signaling pathw... view more»
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