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Hindi La Prensa MedicaISSN: 0032-745X
Martina Iannaccone Author
Subjects of specialization
Affiliation
Transglutaminases; Post-translational modifications of proteins;
Universit
Biography
Martina Iannaccone was working as an Assistant Professor in the Dipartimento di Scienze Mediche, Chirurgiche at the Università degli Studi della Campania "Luigi Vanvitelli and he has research publications on Curcumin (Diferulolylmethane) Reduces Transglutaminase 2 Overexpression Induced by Retinoic Acid in Human Nervous Cell Lines
Publications
Review Article Open Access
Possible Role of the Transglutaminase-Catalyzed Reactions in the Pathogenesis of Neurodegenerative Diseases
Author(s): Martina Iannaccone, Federica Titta, Fabiana Marra, Antonio Martin, Giulia De Vivo and Vittorio Gentile
Possible Role of the Transglutaminase-Catalyzed Reactions in the Pathogenesis of Neurodegenerative Diseases
Transglutaminases are ubiquitous enzymes which catalyze posttranslational modifications of proteins. The main activity of these enzymes is the cross-linking of glutaminyl residues of a protein/ peptide substrate to lysyl residues of a protein/peptide co-substrate. In addition to lysyl residues, other second nucleophilic cosubstrates may include monoamines or polyamines (to form monoor bi-substituted/crosslinked adducts) or –OH groups (to form ester linkages). In absence of co-substrates, the nucleophile may be wat... view more»
DOI: 10.4172/lpma.1000137
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