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Hindi Journal of Pharmaceutics & Drug Delivery ResearchISSN: 2325-9604
Maryam Amini Pouya Author
Subjects of specialization
Affiliation
Aerosol performance
Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Biography
My name is Maryam Amini Pouya- I am from Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran My area of interests are Aerosol performance
Publications
Research Article Subscription
Improvement of Aerodynamic Behavior of Spray-Freeze Dried IgG Powder Applying Amino Acids
Author(s): Shabnam Aghababaie, Fakhrossadat Emami, Maryam Amini Pouya, Behnaz Daneshmand, Maryam Sadat Mirmoeini, Homa Faghihi and Alireza Vatanara
Introduction: Improved stabilization efficiency of processedpowders has been observed via spray freeze drying (SFD) of antibody dried-formulations. The competence of different amino acids was compared with special focus on aerodynamic properties.
Methods: Trehalose in 1:1 of mass ratio to IgG besides Leucine, Phenyl alanine and Glycine in 1:4 and 1:8 of mass ratio to IgG were prepared through SFD. Size-exclusion chromatography (SEC-HPLC) employed to determine the soluble aggregates. Twin stage impinger (TSI), laser light scattering and scanning electron microscopy (SEM) utilized to characterize particle properties. Powder density and thermal behavior analyzed through graduated glass cylinder and differential scanning calorimetry (DSC).
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