Mehmet Ozaslan Author

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MDM2 Gen Polymorphisms at Acute Myeloid Leukemia Patients

Author(s):

Ceren Tekin, Sibel Bayil Oguzkan, Mehmet Ozaslan, Handan Haydaroglu, Isik Didem Karagoz, Ibrahim Halil Kilic , Selin Büdeyri and Mustafa Pehlivan

Purpose: Leukemia is a malignant disease which is caused by bone marrow lymphopoietic or hematopoietic stem cells. Acute myeloid leukemia (AML) is a class of leukemia which indicates phenotypic and genotypic heterogeneity. MDM2 (Murine double minute 2 ) gene is a proto-oncogenes and previously studies in different cancer types shows that polymorphisms in MDM2 gene has connection with these cancer types.

Methods: In this study, it is aimed that to determine whether a relation between MDM2 gene 354 A/G and -410 T/G regions’s single nucleotide polymor... view more»

DOI: 10.4172/2324-9110.1000166

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