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Hindi Journal of Pharmaceutical Sciences & Emerging DrugsISSN: 2380-9477
Mohamed A Osman Author
Subjects of specialization
Affiliation
Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Drag reduction, Drug Therapy
Academy of Sciences, the Human Nutrition Section, Kirkwood Regional Center at the University of Iowa, Coralville, IA, USA
Biography
Mohamed A Osman; Academy of Sciences, the Human Nutrition Section, Kirkwood Regional Center at the University of Iowa, Coralville, IA, USA. Keywords: Adverse Drug Reactions,Drug Action,Drug Delivery,Drug Discovery,Drug interaction,Drug Intoxication,Drug Therapy; Drug Transport and Delivery, Emerging Drugs, Medicinal Chemistry, Pharmaceutical Analysis, Pharmaceutical Design, Pharmaceutical Sciences, Pharmaceutics and Drug Design, Pharmacoepidemiological Studies, Pharmacognosy, Pharmacology
Publications
Research Article Open Access
Quercetin Ameliorates Chronic Type 2 Diabetes Induced by Long-Term High-Fat, High-Sucrose Diet via Modifying Expression of Genes Involved in Energy Homeostasis and Inflammation
Author(s): Almass A Abuzaid, Mohamed A Osman and Abdalla O Elkhawad
Type 2 diabetes (T2D) is a metabolic health disorder that induces aberrant gene expression thought to maintain the disease persistent in absence of the initial triggers. The current T2D therapeutics pose adverse side effects, some of which are hypoglycemia and weight gain-exacerbated insulin resistance. We studied whether regulation of adiponectin (ADIPOQ), glucose transporter -2 (GLUT-2) and C-reactive protein (CRP) genes by quercetin would completely cure T2D induced by longterm consumption of high-fat, high-sucrose diet (HFHSD) in male Wistar rats. Thus, sixty male Wistar rats were randomized into three experimental groups (n=20): normal control (C) fed chow diet,diabetic control (D) fed th... view more»
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