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Hindi Journal of Virology & Antiviral ResearchISSN: 2324-8955
Monique Lafon Author
Subjects of specialization
Affiliation
Biochemistry, Microbiology, Virology, Infectious Diseases
Institut Pasteur- Unit
Biography
Monique Lafon holds a PhD in Biochemistry/Microbiology from the University of Paris Descartes. Monique Lafon is Head of the Viral Neuro-Immunology Laboratory at Institut Pasteur since 2001. She is also, since July 2014, Director of the Virology Department. Her team has discovered that rabies virus has evolved robust mechanisms:
i) to upregulate PD-L1 (B7-H1) at the surface of the infected neurons, allowing the destruction of protective T lymphocytes through a PD-1/PDL-1 mechanism, and
ii) to activate survival signaling pathways leading to the protection of infected neurons against premature apoptosis.
Publications
Research Article Subscription
Ribavirin has an In vitro Antiviral Effect in Rabies Virus Infected Neuronal Cells but Fails to Provide Benefit in Experimental Rabies in Mice
Author(s): Camila Michele Appolin�rio, Christophe Prehaud, Susan Dora Allendorf, Jo�o Marcelo Azevedo de Paula Antunes, Marina Gea Peres, Monique Lafon and Jane Megid
Ribavirin has an In vitro Antiviral Effect in Rabies Virus Infected Neuronal Cells but Fails to Provide Benefit in Experimental Rabies in Mice
The nucleoside analog ribavirin is one of the antiviral drugs recommended in the management of several viral infections in humans. Although ribavirin has been used in rabies treatment, its efficacy has not been formally proven. The objectives were to study the effect of ribavirin on rabies virus (RABV) infection in neuronal cultures, to analyze whether orally-given ribavirin activates an innate immune response in the brain and whether ribavirin confers protection against brain infection in a model of experimental rabies in mice.
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