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Hindi Journal of Pharmaceutical Sciences & Emerging DrugsISSN: 2380-9477
Murdande SB Author
Subjects of specialization
Affiliation
Pharmacology, Pharmaceutical Sciences, Medicinal Chemistry, Drag reduction, Drug Therapy
Worldwide Safety and Regulatory-Global Chemistry, Manufacturing and Controls, Pfizer Worldwide R&D, Groton, USA.
Biography
Murdande SB; Worldwide Safety and Regulatory-Global Chemistry, Manufacturing and Controls, Pfizer Worldwide R&D, Groton, USA.. Keywords: Adverse Drug Reactions,Drug Action,Drug Delivery,Drug Discovery,Drug interaction,Drug Intoxication,Drug Therapy; Drug Transport and Delivery, Emerging Drugs, Medicinal Chemistry, Pharmaceutical Analysis, Pharmaceutical Design, Pharmaceutical Sciences, Pharmaceutics and Drug Design, Pharmacoepidemiological Studies, Pharmacognosy, Pharmacology.
Publications
Review Article Open Access
Evolution of Cancer Stem Cells in Acute Myelogenous Leukemia and Targeting Via Novel Nanotechnology Approaches
Author(s): Murdande SS and Murdande SB
The cancer stem cell model is a hierarchical representation of the asymmetric division of cancer stem cells to form transit-amplifying cells, and ultimately differentiated cancer cells. The model can be applied to Acute Myelogenous Leukemia (AML), a hematopoieticderived cancer. A single tumor population of AML is composed of a minor cancer stem cell subpopulation as well as the majority transit-amplifying cell population. Following treatment of AML with chemotherapy and radiation, the tumors repopulate, as the cancer stem cells remain to regrow the transit-amplifying cell population. This is supported by evidence of an increased number of cancer stem cell markers following relapse of AML, such as CD34, CD38, and CD45 surface markers. Cancer stem cells are th... view more»
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