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Naeser Y Author
Subjects of specialization
Affiliation
Metastatic uveal melanoma; Complete response; NIVO3+IPI1 regimen
Department of Oncology, Uppsala University Hospital, Uppsala, Sweden
Biography
Dr. Naeser Y is working the field Department of Immunology, Genetics and Pathology, Science of Life Laboratory, Uppsala University, Uppsala, Sweden, having specialization in Metastatic uveal melanoma; Complete response; NIVO3+IPI1 regimen
Publications
Case Report Open Access
A Case Report of a Patient with Metastatic Uveal Melanoma who Experienced a Complete Response to Treatment with the NIVO3+IPI1 Regimen
Author(s): Schiza A, Naeser Y, Sundin A and Ullenhag G
Uveal melanoma is a rare malignancy and in the advanced setting there is no effective treatment. Therefore, combined checkpoint blockade with nivolumab 1 mg/kg and ipilimumab 3 mg/kg (NIVO1+IPI3) is frequently used despite low response rates and high immune-related toxicity. There are hardly any reports on the less toxic combination of nivolumab 3 mg/kg and ipilimumab 1 mg/kg schedule (NIVO3+IPI1) in these patients. Case presentation: We used the NIVO3+IPI1 schedule to treat a 56-year-old male suffering from metastatic uveal melanoma. The patient experienced a clear and long-lasting benefit from the treatment. An improvement of his general condition was observed almost immediately after treatment start. A complete metabolic response which is still ongoing was achieved over a year ago an... view more»
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