Nemat Shams Author

Conference Proceeding Open Access

Development of a Novel Chimeric Poly-Epitope Vaccine against COVID-19: A Computer-Aided Study

Author(s):

Nemat Shams

Today, the outbreak of COVID-19 pandemic in December 2019 affected the economy and health around the world then the concern of vaccination against COVID-19 disease is at the top of all country's plans. Objectives: This study was performed to design a safe multi-epitope vaccine based on spike (S), envelope (E), nucleocapsid (N) and membrane (M) proteins of SARS-COVID-2 virus. Methods: In this regard, the most reliable and accurate online tools were used to predict the best B cell, T cell and IFN-γ epitopes of N, S, M and E proteins. Then the best predicted epitopes along with HBHA protein were applied to assemble a novel multi-epitope vaccine using peptide linkers. The physicochemical properties and protein structures of this recombinant vaccine were evaluated using the on line... view more»

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