Noha E Author

Research Article Open Access

Microrna-150 and Microrna-101 As Diagnostic Markers for Hepatitis B Virus Related Hepatocellular Carcinoma in Egypt

Author(s):

Safaa M, Marwa M and Noha E

Background: Hepatocellular carcinoma (HCC) is an increasing difficult problem in Egypt. MicroRNAs are defined as small RNAs that are non-coding RNAs which regulate gene expression after transcription. Circulating microRNAs are promising biological noninvasive markers for cancer.
Aim: The aim of this study was to evaluate miRNAs in Egyptian HBV related Hepatocellular carcinoma and their relation to clinical parameters.
Methods: MiR-150 and miR-101 relative expression were evaluated by real-time quantitative RT-PCR in 70 serum samples (20 from controls, 25 from chronic hepatitis B (CHB) patients and 25 samples from HBV related HCC patients), the diagnosis of HCC was based on typical imaging finding by dynamic computed tomography.... view more»

DOI: 10.4172/2325-9612.1000156

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