Journal of Clinical & Experimental OncologyISSN: 2324-9110

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Numan Fateh Author

numanaf@yahoo.com

Subjects of specialization
Colorectal cancer, Cancer chemotherapy, Prostate biomarker, Endometrial cancer

Affiliation
Department of Hematology and Oncology, Larkin Community Hospital, South Miami, Florida, USA

Biography

Numan Fateh was working in the Department of Hematology and Oncology, Larkin Community Hospital, South Miami, Florida, USA. He has more than 40 publications. His current research area related to osteoarthropathy

Publications

Case Report Open Access

Mantle Cell Lymphoma Misdiagnosed as Chronic Lymphocytic Leukemia: Optimization of Diagnostic Approach

Author(s):

Numan Fateh

Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma that is relatively uncommon. MCL is an aggressive lymphoma and at times can share many features with chronic lymphocytic leukemia (CLL). CLL is positive for CD5+ (in 80% of cases), CD20+ (95%) and CD23+ (85%). MCL is also positive for CD5+ (80%) and CD20+ (94%), but generally negative for CD23-. However, there are cases of CD23 positive MCL which can lead to misdiagnosis. Cyclin D1 is more specific than CD markers, but is positive in approximately 85-90% of cases. Thus for 15% of cases this test is also not reliable to diagnose MCL. For example, there are reports of Cyclin D2 and Cyclin D3 involvement instead of the more commonly known Cyclin D1. The same is true for t (11;14) studies by Fluorescence in situ hybridizatio... view more»

DOI: 10.4172/2324-9110.1000200

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