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Hindi Journal of Otology & RhinologyISSN: 2324-8785
Nyall R London Jr. Author
Subjects of specialization
Affiliation
Inflammatory myofibroblast sarcoma, Radiotherapy, Corticosteroid, Gene, CDKN1B
Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland, USA
Biography
I am Nyall R London Jr. , Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA, Sinonasal and Skull Base Tumor Program, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA
Publications
Case Report Open Access
An Inflammatory Myofibroblastic Sarcoma with CDKN1B Gene Rearrangement: Case Report and Literature Review
Author(s): Lifeng Li, Xiaohong Chen, Lanlan Xuan, Ricardo L Carrau, Nyall R London Jr.
Inflammatory Myofibroblastic Tumor (IMT) and Inflammatory Myofibroblastic Sarcoma (IMS) are uncommon in the Head and Neck region. We present a patient (9 yrs old girl) with IMT from a lacrimal system, undertaking a gross total resection at the department of Ophthalmology, followed by corticosteroid therapy and radiotherapy. After cessation of radiotherapy, the tumor recurred rapid growth rate with the expansion into the entire globe, left paranasal sinuses, and the ipsilateral masseter space and parotid gland. The second surgery with resection of all abovementioned infiltrated structures was performed at the department of Head and Neck, and the pathological outcome turns out to be IMS. However, negative margin could not be achieved. Next generation gene sequencing analysis of whole exom... view more»
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