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Hindi Clinical Oncology: Case Reports
Olga Moser Author
Subjects of specialization
Affiliation
Myofibromatosis, Thoracic Cancer, Medical Oncology, Ovarian Cancer.
Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Pauwelstrasse, Germany
Biography
Dr. Olga Moser is working in the department and Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Medical Faculty, RWTH Aachen University, Pauwelstrasse, Germany. His specialization in the field of the Myofibromatosis, Thoracic Cancer, Medical Oncology, Ovarian Cancer.
Publications
Case Report Subscription
Aggressive Infantile Myofibromatosis with Intestinal Involvement
Author(s): Tristan Romer, Norbert Wagner, Till Braunschweig, Robert Meyer, Miriam Elbracht, Udo Kontny and Olga Moser
Infantile Myofibromatosis (IM) is the most common cause of multiple fibrous tumors in infancy. Multicentric disease can be associated with life-threatening visceral lesions. Germline gain-of-function mutations in PDGFRB have been identified as the most common molecular defect in familial IM. We here describe an infant with PDGFRB-driven IM with multiple tumors at different sites, including intestinal polyposis with hematochezia, necessitating temporary chemotherapy. PDGFRB-driven IM is clinically challenging due to its fluctuating course and multiple organ involvement in the first years of life. Early molecular genetic analysis is necessary to consider tyrosine kinase inhibitor treatment in case of aggressive visceral lesions.
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