Om Prakash Author

Research Article Open Access

Anti-Angiogenic Potential of Secondary Metabolites against Tyrosine Kinase Domain of Vascular Endothelial Growth Factor Receptor-1: An in silico Approach

Author(s):

Upendra N Dwivedi, Aleena Asif, Sameeksha Tiwari, Om Prakash and Veda P Pandey

Angiogenesis, i.e. formation of new blood vessels, is a key hallmark of tumor growth and progression. The tyrosine kinase (TK) domain of vascular endothelial growth factor receptor (TK-VEGFR-1) is reported as the key intracellular domain responsible for the downstream signalling leading to angiogenesis. Therefore, targeting TK domain of VEGFR-1 and blocking downstream signalling is considered as a promising approach in cancer therapy. Furthermore, in view of severe side effects exhibited by present day synthetic drugs, directed against TK domain of VEGFR-1, there is a worldwide effort to identify safer alternatives drugs, especially coming from natural sources. Keeping this perspective in mind, in the present paper, we have evaluated the anti-angiogenic potential of ADMET screened 18 al... view more»

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