Omid Koohi- Hosseinabadi Author

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Calpain in Acute Hepatic Encephalopathy: A Player in Pathophysiology and a Possible Target for Pharmacological Intervention

Author(s):

Mojtaba Farjam, Bahareh Fakhraei and Omid Koohi- Hosseinabadi

 Calpain in Acute Hepatic Encephalopathy: A Player in Pathophysiology and a Possible Target for Pharmacological Intervention

Acute hepatic encephalopathy (AHE) is a rapidly worsening neuropsychiatric syndrome, secondary to acute liver failure (ALF). In most cases, AHE is fatal without liver transplantation. Extending the survival of AHE patients is clinically important, hoping to find appropriate livers for transplantation. Neuroprotection and hepatoprotection can offer future prospects to achieve this goal. Ammonia which is increased in the brain of AHE patients stimulates t... view more»

DOI: 10.4172/lpma.1000122

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