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Hindi Journal of Applied Bioinformatics & Computational BiologyISSN: 2329-9533
Onyeka Solomon Chukwudozie Author
Subjects of specialization
Affiliation
Drug Design, Molecular Dynamics, Simulation Molecular Dynamics, Immunology, Virology
Department of Cell Biology and Genetics, University of Lagos, Yaba, Lagos, Nigeria
Biography
Onyeka Solomon Chukwudozie IS Currently working as a Resaeercher in the University of California at San Diego. He received his Ph.D in the Doctor of Philosophy from University of Claifornia. He is passionated towards science with adept knowledge in Bioinformatics and molecular studies. His current research interts includes Molecular Genetics, DNA Sequence Analysis, Genomics, Mutation, Bioinformatics, Bioinformatics Analysis.
Publications
Research Article Open Access
Phylogenetic and In Silico Analysis of Niemann-pick type C1 (NPC1) Transporter Required for Ebola Viral Entry
Author(s): Onyeka Solomon Chukwudozie
Ebola virus (EBOV) has recently emerged as a highly virulent organism of concern to humans. The pathology behind the hemorrhagic fever within an EBOV host remains largely unclear, and demands rather novel therapeutics to effectively eradicate this virus. The Niemann-pick type C1 (NPC1) protein cholesterol transporter is required for EBOV entry and internalization into a mammalian host cell. On this premise, an organism’s NPC1 can decide the virus-species specificity. Here, the phylogenetic relationships among twelve selected chordates were examined to determine their predicted ligand binding site (LBS). LBS delineates the functional glycosylated part of the NPC1 transporter and mediates in molecular processes. The 13-helix transmembrane of NPC1 and its sub-domains were also assess... view more»
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